PEG

Oleyl Mesylate is a derivative of Oleyl Alcohol, commonly used in various formulations for delivery systems due to its functional properties. The mesyl group serves as a good leaving group for nucleophilic substitution reactions.

DBCO-PEG9-amine represents a bifunctional PEG linker with DBCO group for copper-free catalyzed click chemistry with azides and amine group for reacting with NHS-ester to form an amide bond.

DBCO-PEG-2-Val-Cit-PAB-PNP serves as a cleavable ADC linker derivative where PNP carbonate acts as a highly activated leaving group which may be used to react with amines. The Val-Cit dipeptide can be cleaved by Cathepsin B. The DBCO acts as a click chemistry handle that can react with azides without copper. Water solubility is enhanced via the PEG linker.

SPDP-PEG4-Azide is a PEG linker comprised of an SPDP crosslinker, which is reactive with thiol-containing molecules to form disulfide bonds, and an azide which reacts with DBCO, BCN, and linear alkynes through click chemistry.

Fluorescein-PEG7-Methyltetrazine is a xanthene dye with excitation/emission maximum of 494/517 nm and a terminal tetrazine group. The terminal methyltetrazine enables fast click reactions with TCO (trans-cycloctene). Hydrophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. Reagent grade, for research use only. Please contact us for GMP-grade inquiries.

Methyltetrazine-PEG4-PFP ester operates as a heterobifunctional PEG linker including methyltetrazine, a click chemistry handle used to efficiently react with trans-cyclooctenes (TCO), and PFP ester, an amine-reactive ester that is less susceptible toward hydrolysis compared to NHS ester. The hydrophilicity of the molecule is elevated via the PEG4 spacer.

DBCO-PEG8-amine represents a PEG linker with an azide-reactive DBCO group that participates in copper-free catalyzed chemistry and amine that can be used to derivatize carboxyl groups via activators (e.g. HATU) or NHS ester groups directly.

Bis-sulfone-PEG4-DBCO constitutes a PEG linker with a sulfone and DBCO end group. The sulfone group can be conjugated with thiol groups of proteins. The terminal DBCO can react with azides through copper-free catalyzed click chemistry. The hydrophilic PEG chain increases the water solubility of the compound in aqueous media.

A useful synthetic scaffold consisting of two cis-2-noneyl esters and a free hydroxyl head group which may be further functionalized into an ionizable head group. Reagent grade, for research purpose. Please contact us for GMP-grade.