Results for PEG ( 6339 )
Methyltetrazine-PEG4-Sulfo DBCO constitutes a heterobifunctional PEG linker with a methyltetrazine click chemistry handle that rapidly ligates to trans-cyclooctene (TCO) groups on target molecules and DBCO click chemistry handle that undergoes copper-free reactions with azides. The PEG arm improves the solubility of the compound in aqueous media.
DOTA-PEG3-Methyltetrazine, HCl salt represents a PEG linker including a DOTA group that can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques. Methyltetrazine can be used to react with TCO via click chemistry. The PEG spacer increases the water-solubility.
Sulfo-Cy5.5 tyramide is integral to tyramide signal amplification (TSA), enhancing fluorescent signals in immunohistochemistry (IHC), immunocytochemistry (ICC), and fluorescence in situ hybridization (FISH). Utilizing horseradish peroxidase (HRP), it converts tyramine-containing substrates into reactive radicals. This enables the detection of low-concentration targets and reduces background staining without compromising signal intensity. Sulfo-Cy5.5 tyramide can be used with HRP-conjugated molecules, such as antibodies or streptavidin, for immunofluorescence staining of cells and tissues.
Sulfo-Cy7 tyramide is crucial for enhancing fluorescent signals via tyramide signal amplification (TSA) in immunohistochemistry (IHC), immunocytochemistry (ICC), and fluorescence in situ hybridization (FISH). Through horseradish peroxidase (HRP), it converts tyramine-containing substrates into reactive radicals. This enables the detection of low-concentration targets and reduces background staining without compromising signal intensity. Sulfo-Cy7 tyramide can be used with HRP-conjugated molecules, such as antibodies or streptavidin, for immunofluorescence staining of cells and tissues.
DREADD agonist 21 selectively activates hM3Dq and hM4Di DREADDs, derived from the human muscarinic acetylcholine M3 (hM3) receptor, without affecting the hM3 receptor itself. It has weaker affinities for other receptors (histamine H1, serotonin 5-HT2A, 5-HT2C, and α1A-adrenergic). Used in chemogenetics, it remotely controls neuronal activity, permeates the brain effectively, activating hM3Dq and inhibiting hM4Di DREADDs in vivo. This dihydrochloride salt formulation ensures water solubility.
(E/Z)-4-Hydroxytamoxifen is an active metabolite of tamoxifen and a selective estrogen receptor modulator. It's integral to systems like TRAP/TRAP2, providing genetic access to neuron activity, and is employed in CRISPR/Cas9 gene editing to activate inactivated Cas9 nuclease. Additionally, it acts as an intramembranous lipid peroxidation inhibitor, scavenging peroxyl radicals.