PEG

Biotin-PEG7-methyltetrazine functions as a biotinylating reagent featuring biotin that reacts with amine molecules in the presence of an activator (e.g., EDC or HATU) and methyltetrazine that reacts with TCO-containing compounds without the catalysis of Cu or elevated temperatures.

Biotin-PEG12-Picolyl azide features an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) with linear alkyne-containing molecules, with the picoyl azide moiety increasing the efficiency and speed of the CuAAC reaction for improved biocompatible labeling. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups without a copper catalyst.

2,3-dihydroxypropyl carbamate-PEG-m, MW 1,000

Methyltetrazine-amido-N-bis(PEG4-DBCO) represents a PEG derivative that includes a methyltetrazine group and two DBCO groups. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules. The PEG4 chains increase the water solubility of the compound.

nonadeca-1,18-dien-10-yl 4-bromobutanoate

Methyltetrazine-PEG7-maleimide serves as a bifunctional PEG linker comprised of methyltetrazine, which is reactive toward trans-cyclooctenes, and maleimide, which is reactive towards thiol-bearing moieties. The additional methyl on the methyltetrazine enhances the stability of the group. The PEG link enhances solubility in aqueous media.

DOTA-PEG5-TCO is a PEG linker containing DOTA and TCO moieties. TCO is a click chemistry handle that readily reacts with tetrazine groups on a target molecule. The DOTA group can be ionized and is susceptible to chelating di- and trivalent cations. DOTA can also be used for imaging diagnostic techniques.

3,7,11-trimethyldodecyl 6-bromohexanoate

m-PEG2-alcohol