PEG

3,4-Dibromo-Mal-PEG2-Acid constitutes a PEG linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. Dibromo-Maleimide is sensitive to high temperature and light. The carboxylic acid can react with primary amines in the presence of coupling agents such as EDC and HATU. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

PC Biotin-PEG8-NHS carbonate ester is useful for introducing a biotin moiety to amine-containing biomolecules directly and efficiently. The hydrophilic PEG arm provides better solubility to the labeled molecules in aqueous media. Captured biomolecules can be efficiently photoreleased using near-UV, low intensity lamp (e.g. 365 nm lamp at 1-5 mW/cm2).

Bis-PEG5-Methyltetrazine represents a bifunctional PEG linker where methyltetrazine enables a fast click reaction with TCO (trans-cycloctene).

Picolyl azide-PEG4-NHS ester is a bifunctional PEG linker comprised of a picolyl moiety that assists with a copper-chelating system within its structure, lowering the amount of copper catalyst required in the CuAAC reaction for the azide and an NHS ester that directly and efficiently reacts with amine-bearing moieties. The PEG4 chain improves the compound's water solubility.

BP Lipid 449 is a novel analog of the ionizable lipid LP01 whose key feature is the introduction of a bis cyclopropyl fatty acid tail. This alteration has been designed to investigate the effect on the dynamics of lipid nanoparticles as cyclopropane fatty acids have been reported to affect the fluidity and structure of lipid bilayers in response changes in temperature and pH (J. Phys. Chem. B 2014, 118, 48, 13838–13848). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Palmitic acid-PEG23-amine is a PEG lipid that contains palmitic acid, a saturated fatty acid, connected to an NHS ester-reactive, terminal amine via a PEG23 chain, which bolsters the water-solubility of the lipid for efficient drug delivery.

N-Mal-N-bis(PEG4-acid-amido-PEG24-t butyl ester) serves as a branched maleimide ester. The maleimide group will react with a thiol group, enabling the connection of a biomolecule with a thiol. The t-butyl ester can be hydrolyzed under acidic conditions. The hydrophilic PEG spacers enhance the water-solubility of the molecule.

N-Mal-N-bis(PEG4-acid-amido-PEG24-acid) functions as a maleimide PEG reagent with two terminal carboxylic acids and a maleimide (Mal) group. Maleimide (Mal) reacts specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The terminal carboxylic acids can conjugate with amine-containing molecules in the presence of activators (e.g. HATU). The PEG linkages improve the compound's water solubility.

DOTA-PEG8-amine, HCl salt represents a PEG linker possessing a DOTA moiety, which can be used as a chelating agent for cations and is commonly used for imaging diagnostics. The amine group is reactive toward carboxylic acids, activated NHS esters, etc. The hydrophilic PEG chain enhances the solubility of compounds in aqueous media.