VHL Ligand 14 is a ligand that interacts with the VHL E3 ligase, facilitating the development of PROTACs for targeting estrogen receptor α (ERα). Its structural properties enable effective binding and integration into degrader systems.
VL285 is a highly effective ligand for the VHL E3 ligase, featuring strong binding affinity. Its structural characteristics make it a valuable tool for applications involving VHL-mediated protein degradation.
TD-106 is a cereblon (CRBN) modulator that facilitates targeted protein degradation. It enables the use of BRD4 PROTACs to specifically promote the degradation of the BRD4 protein.
KB02-COOH is a fragment used in the synthesis of the ubiquitin E3 ligase ligand KB02. This ligand plays a role in the creation of PROTACs, enabling targeted protein degradation in compounds like KB02-JQ1 and KB02-SLF.
NV03 is a selective antagonist that disrupts the interaction between UHRF1 and H3K9me3 by binding to the UHRF1 tandem tumor domain. Its structural features make it valuable for studying UHRF1-related protein interactions.
cIAP1 ligand 1 is an IAP ligand derived from LCL161. It can be linked to an ABL-targeting ligand via a linker to form a SNIPER construct, enabling targeted protein degradation.
CRBN modulator-1 is a Thalidomide analog that functions as a cereblon (CRBN) modulator. Its structural properties make it useful for studying CRBN-related protein interactions.
E3 ligase Ligand 8 is a ligand that targets E3 ubiquitin ligase and can be linked to a protein-targeting ligand via a linker to create PROTACs. These structures facilitate ubiquitination-mediated protein degradation.
