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PP-C8 is a selective PROTAC that targets the degradation of the CDK12-Cyclin K complex. By facilitating the removal of these proteins, PP-C8 enhances the potential for synergistic effects when used in combination with PARP inhibitors, particularly in the context of triple-negative breast cancer.

VEGFR-2-IN-39 is a PROTAC designed to specifically target VEGFR-2, exhibiting low toxicity. This compound effectively inhibits the proliferation of EA.hy926 cells, a line derived from human umbilical vein endothelial cells, in a concentration-dependent manner. Its structural composition enables effective interaction with VEGFR-2, making it useful for studying vascular-related pathways.

PROTAC MDM2 Degrader-1 employs PROTAC technology to target and degrade MDM2. It consists of a potent MDM2 inhibitor linked to a ligand that interacts with E3 ubiquitin ligase, facilitating selective protein degradation. This structural design enhances the compound's ability to modulate protein levels effectively through targeted ubiquitination mechanisms.

PROTAC BRD9 Degrader-4 is a bifunctional degrader targeting BRD9, designed for use in cancer research. Its structural components enable effective protein degradation, facilitating the study of BRD9's role in cancer biology.

PROTAC BET Degrader-1 is a bifunctional molecule that links Cereblon and BET ligands, effectively reducing the levels of BRD2, BRD3, and BRD4 proteins. Its functional groups enable targeted protein degradation at low concentrations

PROTAC BRD4 Degrader-1 is a bifunctional molecule linking Cereblon and BRD4 ligands, designed to target and degrade BRD4 protein. Its structure enables effective reduction of BRD4 levels and modulation of c-Myc expression.

PROTAC ERα Degrader-1 is a molecule consisting of an E3 ligase ligand, a linker, and an estrogen receptor-alpha (ERα) targeting group, facilitating targeted degradation of ERα.

HDAC6 Degrader-1 is a PROTAC that utilizes Nexturastat A as a selective HDAC6-binding component, combined with a linker and an E3 ligase-recruiting ligand. This structure promotes targeted degradation of HDAC6, offering strong selectivity over other HDAC enzymes and effectively inhibiting cell proliferation.

MI-389 is a PROTAC designed to degrade the translation termination factor GSPT1. It disrupts a critical target shared across various AML and ALL cell lines, with its activity dependent on CRL4 CRBN E3 ligase recruitment.