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MS4077 is a PROTAC designed to target anaplastic lymphoma kinase (ALK), featuring a Cereblon ligand for effective protein degradation. Its structural configuration allows for strong binding affinity to ALK, facilitating targeted protein modulation.

SR-1114 is a novel PROTAC that selectively degrades the ENL protein through a CRBN-dependent mechanism. Its structural design enables efficient and rapid targeting of ENL in various cell lines, facilitating studies on protein turnover and regulatory pathways.

CFT1946 is an orally active bifunctional degradation activating compound designed for selective degradation of the BRAF V600E mutant through a CRBN-based mechanism. Its structural features enable it to effectively target various BRAF mutations, including G469A, G466V, and the p61-BRAF V600E splice variant, making it valuable for investigating tumor biology.

RSS0680 is a bifunctional compound designed for the targeted degradation of various kinases. Its structural composition facilitates the degradation of multiple kinases, including AAK1, CDK1, CDK2, CDK4, and others, making it useful for exploring conditions associated with dysregulated kinase activity.

PROTAC KRAS G12C degrader-1 is a Cereblon-based compound designed to target and degrade the KRASG12C protein. It promotes the dimerization of CRBN with KRASG12C, effectively facilitating the degradation of GFP-tagged KRASG12C in reporter cell systems.

PROTAC CBP/P300 Degrader-1 is an effective compound designed to target and degrade the CBP and p300 proteins. It demonstrates strong inhibitory effects on cell viability across various cancer cell lines.

PROTAC MDM2 Degrader-3 is an advanced MDM2 degrader utilizing PROTAC technology. This compound consists of a strong MDM2 inhibitor, a linking moiety, and an MDM2 ligand designed to engage with E3 ubiquitin ligase, facilitating targeted degradation of MDM2.

ARD-266 is a highly effective PROTAC degrader targeting the Androgen Receptor (AR) through von Hippel-Lindau E3 ligase. This compound facilitates the degradation of AR protein in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1. Featuring an alkyne functional group, ARD-266 also serves as a click chemistry reagent, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.

MG-277 is a molecular glue degrader that targets the translation termination factor GSPT1 via the Cereblon E3 ligase pathway. This compound effectively facilitates the degradation of GSPT1 and demonstrates significant inhibition of tumor cell growth in a p53-independent manner. Its structural features enable potent interactions with cellular components, contributing to its effectiveness in research settings focused on cellular regulation and potential therapeutic applications.