CRBN modulator-1 is a Thalidomide analog that functions as a cereblon (CRBN) modulator. Its structural properties make it useful for studying CRBN-related protein interactions.
E3 ligase Ligand 8 is a ligand that targets E3 ubiquitin ligase and can be linked to a protein-targeting ligand via a linker to create PROTACs. These structures facilitate ubiquitination-mediated protein degradation.
Cereblon inhibitor 1 is an isoindoline derivative which acts as a modulator of the cereblon E3 ubiquitin ligase. Its structural features make it valuable for studying cereblon-related protein interactions.
VH101, thiol is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal thiol group, designed for PROTAC development. It enables conjugation with a target protein-ligand for use in E3 ligase-mediated degradation systems.
E3 ligase Ligand 18 is designed to target E3 ubiquitin ligase and can be linked to a protein ligand via a connector to create PROTACs, which facilitate ubiquitin-mediated degradation of specific proteins.
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) ligand designed for PROTAC research. It features an E3 ligase ligand and an alkyl linker with a terminal amine, facilitating conjugation to a target protein ligand.
AR antagonist 1 is a potent androgen receptor (AR) antagonist that interacts with E3 ligase ligands, showing weak binding affinity to the VHL protein in the synthesis of PROTAC ARD-266.
E3 ligase Ligand 23 is a cereblon binder that facilitates the degradation of the Ikaros or Aiolos transcription factors through the ubiquitin-proteasome pathway.
