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OARV-771 is a derivative of ARV-771, which is a potent PROTAC targeting bromodomain and extraterminal (BET) proteins, utilizing the von Hippel-Lindau E3 ligase for targeted degradation. This compound features selective binding affinity for various BRD proteins, demonstrating its potential utility in research focused on modulating BET protein functions.

Thalidomide-NH-CBP/p300 ligand 2 is a PROTAC designed to induce the degradation of CBP and p300 through targeted protein degradation mechanisms.

PROTAC KRAS G12C degrader-2 is a bifunctional molecule that modulates K-Ras protein hydrolysis. It combines a cereblon-targeting ligand with a KRAS-binding moiety to facilitate targeted degradation of KRAS.

Dovitinib RIBOTAC is a selective RNA degrader designed to target and cleave pre-miR-21, offering enhanced potency and specificity in RNA degradation.

PROTAC HER3 Degrader-8 is a bifunctional molecule designed to induce the degradation of HER3 protein in vitro and in cellular assays, useful for investigating pathways involving HER family proteins.

SJF-0628 is a PROTAC designed to selectively degrade mutant BRAF proteins. It targets specific BRAF variants, making it useful for studying conditions linked to RAF protein aggregation, accumulation, or persistent activation.

PROTAC EGFR Degrader 2 is a highly potent compound that effectively targets EGFR for degradation. It demonstrates strong antiproliferative properties and can be utilized in the synthesis of nitroreductase-responsive PROTACs.

HDAC6 Degrader-3 is a selective compound that facilitates HDAC6 degradation through ternary complex formation and the ubiquitin-proteasome system. It shows significant selectivity for HDAC6 over HDAC1 and induces marked hyperacetylation of α-tubulin.

CMP98 is a PROTAC that does not promote VHL degradation and serves as a negative control for CM11. It features two von Hippel-Lindau ligands within its active structure.