Activators & Inhibitors

Biotinylation reagent with a pentafluorophenyl ester group. More reactive than the NHS ester group, targeting both primary and secondary amines. Suitable for biotin labeling of both proteins and amino acids.

Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction. Novo-TRX is Texas Red-labeled novobiocin, which can be used as a fluorescence probe in assays for screening DNA gyrase inhibitors.

Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction.

Bromosporine is a broad spectrum inhibitor for bromodomains.

EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 400 pM. EPZ004777 selectively kills a variety of MLL-rearranged leukemia cells, including an MLL-AF4 leukemia cell line MV4-11 and an MLL-AF9 leukemia cell line MOLM13.

Sodium Phenylbutyrate is a transcriptional regulator that acts by altering chromatin structure via the modulation of HDAC activity.

Tankyrase Inhibitor 22 (TNKSi22) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tankyrase Inhibitor 49 (TNKSi49) is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0.1 nM.

Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor . Tubacin does not inhibit HDAC6 histone deacetylase activity; instead, tubacin is specific for the tubulin deacetylase activity of HDAC6. It reversibly inhibits α-tubulin deacetylation in mammalian cells and increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.