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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70877 )

      • MeBIO

        Ref: T21966
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        MeBIO (Legacy Tebubio ref. 282T21966). MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.

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      • MEG hemisulfate

        Ref: T21967
        Sizes: 1 mg, 5 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        MEG hemisulfate (Legacy Tebubio ref. 282T21967). MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.

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      • MG-262

        Ref: T21968
        Sizes: 1 mg, 200 μg

        MG-262 (Legacy Tebubio ref. 282T21968). MG-262 is a reversible proteasome inhibitor with multiple biological activities (MGCD-162, Mills 2004) (Morrison et al., 2005, Li et al., 2006) (Tang et al., 2006, Zhang et al., 2007).

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      • ML-095 hydrochloride

        Ref: T21969
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg, 2 mg, 1 mL * 10 mM (in DMSO)

        ML-095 hydrochloride (Legacy Tebubio ref. 282T21969). ML-095 hydrochloride (CID-25067483 hydrochloride) is a specific placental alkaline phosphatase inhibitor. It inhibits PLAP, TNAP and IAP with IC50 of 2.1, >100 and 53 μM, respectively.

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      • 10-Deacetylbaccatin III

        Ref: T2197
        Sizes: 100 mg, 1 mL * 10 mM (in DMSO)

        10-Deacetylbaccatin III (Legacy Tebubio ref. 282T2197). 10-Deacetylbaccatin-III is an intermediate for the preparation of taxol analogs, possessing anti-cancer activity.

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      • ML-097

        Ref: T21970
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        ML-097 (Legacy Tebubio ref. 282T21970). ML-097 (CID-2160985) is a universal activator of Ras-related GTPases.

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      • ONO-8130

        Ref: T21976
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg

        ONO-8130 (Legacy Tebubio ref. 282T21976). ONO-8130 is an orally available antagonist of EP1 receptor.

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      • p-Cresyl sulfate

        Ref: T21977
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        p-Cresyl sulfate (Legacy Tebubio ref. 282T21977). p-Cresyl Sulfate is the major uremic toxin present in the blood of patients with chronic kidney disease and is derived from the metabolites of tyrosine and phenylalanine in the liver.

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      • p-nitro-Pifithrin-α

        Ref: T21978
        Sizes: 1 mg, 5 mg, 25 mg, 10 mg

        p-nitro-Pifithrin-α (Legacy Tebubio ref. 282T21978). p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

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