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Activators & Inhibitors

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    Results for Activators & Inhibitors ( 70877 )

      • HA 155

        Ref: T22086
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg

        HA 155 (Legacy Tebubio ref. 282T22086). HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.

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      • HLI 373

        Ref: T22087
        Sizes: 25 mg, 50 mg

        HLI 373 (Legacy Tebubio ref. 282T22087). HLI373 is an efficacious Hdm2 inhibitor, an ubiquitin ligase (E3), effective in inducing apoptosis of several tumor cells sensitive to DNA-damaging agents [1], and also shows prominent antimalarial activity [2].

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      • HPI 1

        Ref: T22089
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)

        HPI 1 (Legacy Tebubio ref. 282T22089). HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation).

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      • Serotonin hydrochloride

        Ref: T2209
        Sizes: 25 mg, 100 mg, 50 mg, 200 mg, 1 mL * 10 mM (in DMSO)

        Serotonin hydrochloride (Legacy Tebubio ref. 282T2209). Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).

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      • Imiquimod hydrochloride

        Ref: T22091
        Sizes: 100 mg, 50 mg

        Imiquimod hydrochloride (Legacy Tebubio ref. 282T22091). Imiquimod hydrochloride (R 837 hydrochloride), a selective toll-like receptor 7 (TLR7) agonist, functions as an immune response modifier with in vivo antiviral and antitumor properties, and is utilized in researching external genital and perianal warts, cancer, and COVID-19 [1] [2].

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      • Indomethacin heptyl ester

        Ref: T22092
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 500 mg, 10 mg, 2 mg, 1 mL * 10 mM (in DMSO)

        Indomethacin heptyl ester (Legacy Tebubio ref. 282T22092). Indomethacin heptyl ester is a non-selective inhibitor of both COX-1 and COX-2

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      • JGB1741

        Ref: T22094
        Sizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg

        JGB1741 (Legacy Tebubio ref. 282T22094). JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.

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      • L 012 sodium salt

        Ref: T22096
        Sizes: 1 mg, 5 mg, 25 mg, 50 mg, 10 mg, 1 mL * 10 mM (in DMSO)

        L 012 sodium salt (Legacy Tebubio ref. 282T22096). L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox) to find Nox inhibitors.

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      • Genipin

        Ref: T2210
        Sizes: 100 mg, 50 mg, 20 mg, 1 mL * 10 mM (in DMSO)

        Genipin (Legacy Tebubio ref. 282T2210). Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.

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