Results for Activators & Inhibitors ( 70845 )
- Ref: T22624LSizes: 1 mg, 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 200 mg
Dolastatin 10 trifluoroacetate (Legacy Tebubio ref. 282T22631). Dolastatin 10 trifluoroacetate is a potent antimitotic polypeptide isolated from a marine animal and is developed as a potential antitumor agent. Dolastatin 10 is found to have an activity to inhibit tubulin polymerization (IC50: 1.2 μM). Besides that, it potently inhibits vincristine binding to tubulin (Ki: 1.4 μM in a non-competitive manner). Dolastatin 10 also shows a moderate effect on enhancing the binding of colchicines to tubulin. In addition, Dolastatin 10 has the inhibitory activity in tubulin-dependent GTP binding.
CCT251545 analogue, Compound 51 (Legacy Tebubio ref. 282T22633). CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastric and colorectal cancers through the activation of WNT signaling.