Activators & Inhibitors

I-CBP112 (Hydrochloride) is a selective inhibitor of cAMP responsive-element binding protein (CREBBP) and E1A binding protein p3000 (EP3000). The inhibitor has been shown to decrease EZH2 activity and to inhibit trimethylation of lysine 27 on histone H3 in cultured human AML HL-60 and OCI-AML3 cells. It has the same effect on primary AML cells in a dose-dependent manner.

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

Telotristat is the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.

(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.

UNC 1215 is a methyl-lysine inhibitor. UNC1215 inhibits L3MBTL3 with 50x more potency than other MBT family members.

UNC 1215 is a methyl-lysine inhibitor. UNC1215 inhibits L3MBTL3 with 50x more potency than other MBT family members.