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IC<sub>5<sub>-OSu special packaging is ued as fluorescent labeling reagent. IC5 is an indocyanine dye that can react with amine groups on proteins, peptides, and amine-modified oligonucleotides. Due to the absence of a sulfonate group in its structure, the water-solubility of the molecules is very low, necessitating the use of an organic solvent for dissolution. Furthermore, as no negative charge is added to the protein, the total number of charges on the modified protein remains the same before and after labeling with these compounds.