Lipids & Polymers

t-butyl ester-PEG25-Amide-Tri(3-methoxypropanamide-PEG23-Azide) Methane is a branched PEG linker with a terminal t-butyl group and three terminal azide groups. The t-butyl group can be deprotected under acidic conditions. The azide groups enables PEGylation via Click Chemistry.

Amine-Tri(3-methoxypropanamide-PEG23-Azide) Methane HCl salt is a branched PEG linker with a terminal amine group and three terminal azide groups. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The azide groups enables PEGylation via Click Chemistry.

t-Boc-Aminooxy-PEG10-acid is a PEG linker containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form an amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The Boc-protected amine can be deprotected under mild acidic conditions.

PEG8-bis(C3-amine) is a conjugation linker containing two amine groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

DSPE-PEG-COOH, MW 3,400 is a widely used phospholipid-PEG in drug delivery applications which allows hydrophobic drugs to be encapsulated. The carboxylic acid functional group can react with primary amine to form a stable amide bond in the presence of EDC or HATU.

DSPE-PEG-COOH, MW 1,000 is a widely used phospholipid-PEG in drug delivery applications which allows hydrophobic drugs to be encapsulated. The carboxylic acid functional group can react with primary amine to form a stable amide bond in the presence of EDC or HATU.

MZ1 is a PROTAC compound that is selective for proteasomal degradation of bromodomain-containing protein 4 (BRD4) in HeLa cells . MZ1 contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Pomalidomide-PEG4-Ph-NH2 comprises the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporatess PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.