Lipids & Polymers

Cy5-DSPE is a dye containing a hydrophilic phosphate head and hydrophobic lipid tails. This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. This molecule can be considered a non-reactive dye for the use in control samples, and for instrument calibration. The phospholipid can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposomes in mRNA or DNA vaccines.

Biotin-S-S-PEG-silane, MW 2,000 is a cleavable reagent for introduction of a biotin moiety to silane with hydroxyl (OH) functional group. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME, and TCEP.

(9Z,12Z)-3-(4,4-bis(octyloxy)butanoyloxy)-2-(hydroxymethyl)propyl octadeca-9,12-dienoate is a lipid component featuring a linoleic fatty acid, a primary alcohol, and a symmetrical aliphatic acetal.

3,6-bis(4-aminobutyl)-2,5-piperazinedione, HCl salt

2,5-dioxopyrrolidin-1-yl 6-bromohexanoate is an alkane linker with a terminal bromide and an NHS ester. The bromide is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

4,4-bis(octyloxy)butanoic acid sodium salt is a chemical reagent featuring a butanoic acid and an acetal linking it to two identical saturated C8 tails. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.

8-Bromo-octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester is an alkane linker with a terminal bromide and an NHS ester. The bromide is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

2-(4-{2-[(2-aminoethyl)amino]ethyl}piperazin-1-yl)ethan-1-amine

Heptadecan-9-amine has an amine group which is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.