Lipids & Polymers

4-(5-Nitropyridin-2-yl)disulfanyl)pentanoic acid is a synthetic building block with terminal nitro and carboxylic acid groups with a disulfide bond in the center.

t-Butoxycarbonyl-PEG3-NHS ester has a t-Boc protecting group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

N-(t-butyl ester-PEG3)-N-bis(PEG3-azide) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of azide groups. The azide groups are very reactive with alkynes such as DBCO, BCN and propargyl via Click Chemistry. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

Bis-PEG12-NHS ester is composed of 12 PEG units with two amino groups. Amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

Methyltetrazine-PEG5-amine HCl salt is an aqueous soluble PEGylation reagent containing a free amine and a methyltetrazine group. The methyl group improves the stability and the hydrophilic PEG spacer increases water-solubility. Methyltetrazine enables fast click reaction with TCO (trans-cycloctene).

N-(t-butyl ester-PEG3)-N-bis(PEG3-amine) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of amine groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

N-(t-butyl ester-PEG3)-N-bis(PEG3-Mal) is a branched conjugation reagent with a terminal t-butyl group and a terminal pair of maleimide groups. The maleimide group will react with a thiol group to form a covalent bond. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacer increases the hydrophilic properties of the compound.

Methyltetrazine-PEG5-NH-Boc is a click chemistry crosslinker containing methyltetrazine and a Boc protecting group. Methyltetrazine enables fast click reaction with TCO (trans-cycloctene). The hydrophilic PEG spacer arm improves water solubility and is transferrable to the labeled molecule, reducing aggregation of labeled proteins stored in solution. The Boc protecting group can be removed under acidic conditions.

DMPE-mPEG, MW 2000, is a DMPE-PEGylated compound with a methyl group at the other end of the PEG chain. The PEG polymer exhibits amphiphatic behavior and helps to form stable micelles in an aqueous solution. It can be used to prepare nanoparticles or liposomes for targeted drug delivery applications.