Lipids & Polymers

3-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research.

3-(5-iodo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research.

t-butyl ester-PEG5-CH2COOH is a PEG linker containing a t-butyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl group can be deprotected under acidic conditions.

t-Boc-N-amido-PEG5-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

S-heptadecan-9-yl ethanethioate is a lipid molecule with a C17 chain linked to a thioacetate.

N-(NHS ester-PEG3)-N-bis(PEG3-Mal) is a 3-arm PEG reagent with an NHS ester group and two maleimide moieties that are reactive toward thiols. Maleimide groups react specifically with sulfhydryl groups to form a stable thioether linkage when the pH is between 6.5 and 7.5. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Propargyl-PEG3-CH2CO2H is an PEG linker with an alkyne and carboxylic acid set of functional groups. The alkyne group can participate in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage. The carboxylic acid can react with primary amines to form stable amide bonds; activator (e.g. EDC, or HATU) is needed.

HO-PEG-acid, MW 1,000 is a heterobifunctional PEG polymer which can react with amine in the presence of an activating agent, such as HATU or EDC.

Tri(propargyl-PEG5-NHCO-ethyloxyethyl)amine is a click chemistry branched linker. The propargyl groups can react with azide-bearing molecules via copper catalyzed Click Chemistry.