Lipids & Polymers

Bromoacetamido-PEG4-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide. The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.

L319, also known as O-8670, is a novel ionizable biodegradable lipid for delivery of short interfering RNA (siRNA) and mRNA via lipid nanoparticles (LNPs). L319-LNP displays rapid elimination with a pKa of 6.38. Reagent grade, for research use only.

306Oi10 is a novel ionizable, biodegradable lipid for delivery of short interfering RNA (siRNA) via lipid nanoparticles (LNPs). The pKa is 6.4.

t-Boc-N-Amido-PEG10-propargyl is a propargyl linker with one side protected by Boc group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc protected amine can be deprotected under mild acidic conditions.

Amino-PEG19-amine is a PEG linker containing two amine functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc.

2-(Propargyl-PEG4-amido)-1,3bis(PEG1-methyl ester) is a crosslinker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The methyl ester groups can be hydrolyzed, reduced, or substituted under different conditions.

DSG-PEG, MW 2,000 also called PEG-1,2-distearoyl-rac-glycero-3-methylpolyoxyethylene 2000, is used for liposome preparation. DSG-PEG, MW 2,000 has become known for lipid nanoparticle (LNP) preparation for small interfering RNA (siRNA) delivery research.

DSPE-PEG-Mannose, MW 10,000 is a PEG polymer containing DSPE and Mannose end groups. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.

DSPE-PEG-Mannose, MW 20,000 is a PEG polymer containing DSPE and Mannose end groups. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. D-glucose increases solubility in aqueous media and increases the selectivity of the PEGylation reaction.