Lipids & Polymers

6-(3-hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The ethanolamine lipid head enhances encapsulation of mRNA. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.

Palmitamide-PEG2-amide-PEG2-acid is a saturated long-chain fatty acid with a 16-carbon backbone and PEG linker containing a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

Palmitamide-PEG2-amide-PEG2-NHS ester is a saturated long-chain fatty acid with a 16-carbon backbone and a PEG linker containing a terminal NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

PEG-bis-CH2CO2H, MW 3,400 is a homobifunctional PEG polymer containing terminal carboxylic acid moieties. The carboxylic acid can react with primary amines to form a stable amide bond.

PEG-bis-CH2CO2H, MW 10,000 is a homobifunctional PEG polymer containing terminal carboxylic acid moieties. The carboxylic acid can react with primary amines to form a stable amide bond.

PEG-bis-CH2CO2H, MW 20,000 is a homobifunctional PEG polymer containing terminal carboxylic acid moieties. The carboxylic acid can react with primary amines to form a stable amide bond.

bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid-like compound containing four hydrophobic tails bound by esters. It can be used to build lipids for mRNA encapsulation and delivery.

heptadecan-9-yl 10-bromodecanoate is an intermediate for the synthesis of lipid molecules.

(6Z,16Z)-12-(Z)-dec-4-enyl)docosa-6,16-dien-11-ol is an intermediate for the synthesis of lipid molecules.