Lipids & Polymers

DSPE-Polysarcosine150 is a a nonionic and hydrophilic polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 150 sarcosine units. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is comprised of phosphorylethanolamine phospholipid acylated with fully saturated C18 fatty acids. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. DSPE-Polysarcosine can be used in lipid formulas to create lipid nanoparticles (LNPs) for therapeutic applications of mRNA.

Azide-Polysarcosine20 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 20 sarcosine units. The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. Azide-Polysarcosine can be used to create lipids for the formation of lipid nanoparticles (LNPs) to be used in therapeutic application of messenger RNA.

Azide-Polysarcosine100 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 100 sarcosine units. The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. Azide-Polysarcosine can be used to create lipids for the formation of lipid nanoparticles (LNPs) to be used in therapeutic applications of mRNA.

Azide-Polysarcosine150 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 150 sarcosine units. The azide can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG) lipids. Azide-Polysarcosine can be used to create lipids for the formation of lipid nanoparticles (LNPs) to be used in therapeutic applications of mRNA.

Polysarcosine20 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 20 sarcosine units. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG).

Polysarcosine150 is a lipid-polypeptoid conjugate based on the endogenous amino acid sarcosine (N-methylated glycine) with an average of 150 sarcosine units. Polysarcosine has been shown to have a higher protein secretion with a reduced immunostimulatory response observed when compared to systems based on polyethylene glycol (PEG).

PEI-b(2k)-mPEG(5k) is a linear amphiphilic block copolymer comprised of polyethylene glycol (PEG) and poly(ethylene imine) (PEI). The hydrophilic PEG increases solubility in aqueous media. PEI has temperature dependent solubility in aqueous media and finds many applications in industry. PEI-b-mPEG can be used in the development of lipid nanoparticles. The terminal hydroxyl group enables further derivatization or replacement with other reactive functional groups.

PEI-g(25k)-PEG(1k), 10% PEG ratio is a graft copolymer of branched PEI (bPEI), which is modified with a 10% ratio of 1,000 MW PEG. Branched PEI shows a variable solubility in water and can have a wide amount of uses in industry. The hydrophilic PEG spacer increases solubility in aqueous media. Copolymers of cationic poly(ethyleneimine) grafted with polyethylene glycol (PEG) (PEI-g-PEG) can improve the in vitro and in vivo delivery of antisense oligonucleotides (ASOs) to cells and tissues. PEG-PEI-ASO nanoparticulates can be prepared with a dynamic range of size, surface charge, and stability by varying the MW of PEI, as well as the nature of PEG shielding. PEG-PEI copolymers are readily functionalized for enhanced efficacy and specificity of cellular and tissue targeting.

Azide-pGlu, MW 2,500 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal azide group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.