Results for Lipids & Polymers ( 10111 )
Azide-pGlu, MW 10,000 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal azide group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
OPSS-PGlu, MW 5,000 is a synthetic polyamino acid having one COOH function per glutamic acid unit and a terminal Orthopyridyl disulfide (OPSS) group. pGlu is soluble in water(alkaline solution), dichloroacetic acid, chloroform, DMF(warm), and dioxane. The terminal OPSS group can selectively react with free thiol, SH, sulfhydryl or mercapto to form reversible disulfide bonds.
PLGA(1.4k)-PEG(1k)-PLGA(1.4k) is a large PEG-PLGA conjugate containing a two hydrophobic poly(lactide-co-glycolide) groups linked together by a hydrophilic PEG spacer. PLGA is often used in forming lipid nanoparticles for drug delivery, for which it is highly valued as it is also biodegradable along its ester bonds. PLGA can also be functionalized at its terminal secondary alcohols to further expand its chemical complexity.
BP Lipid 227 is an ionizable lipid. The ethanolamine amino lipid head enhances encapsulation of mRNA. The lipid has primary esters at C5 position relative to the amine nitrogen. The primary lipid tail has an 8 carbon tail. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
BP Lipid 228 is an ionizable lipid. The dimethylamine lipid head enhances encapsulation of mRNA. The lipid has a C5 amide connection and two primary esters at C8 position relative to the amide nitrogen. The primary lipid tail has a mixture of 4 and 6 carbon tails. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. The pKa is 6.5. Reagent grade, for research use only.
PEI-g(10k)-PEG(5k), 10% PEG ratio is a graft copolymer of branched PEI (bPEI) which is modified with a 5 kDa mPEG along 10% of its residues. bPEI shows variable solubility in water, which is improved through the inclusion of hydrophilic PEG residues. These copolymers can be used to improve drug delivery of oligonucleotides. Altering the MW or % PEG of a PEI copolymer will alter a number of factors crucial to ADME such as size, surface charge, and stability. Finally, PEI-PEG copolymers are easily functionalized along the many primary amines in the PEI structure.
PEI-g(10k)-PEG(5k), 20% PEG ratio is a graft copolymer of branched PEI (bPEI) which is modified with a 5 kDa mPEG along 10% of its residues. bPEI shows variable solubility in water, which is improved through the inclusion of hydrophilic PEG residues. These copolymers can be used to improve drug delivery of oligonucleotides. Altering the MW or % PEG of a PEI copolymer will alter a number of factors crucial to ADME such as size, surface charge, and stability. Finally, PEI-PEG copolymers are easily functionalized along the many primary amines in the PEI structure.
PLLA(30k)-PEG(5k)-NH2 is a functional amphiphilic block copolymer (ABC) which has amine group at the end of PEG block. The amine group is reactive with activated NHS esters, carbonyls (ketone, aldehyde), etc. PLA-PEG is one of the most commonly used biodegradable ABC polymers for drug delivery. Reagent grade, for research use only.