Results for Lipids & Polymers ( 10111 )
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3. This analog of PI(4 5)P2 is labeled with the red fluorophore Cyanine 5 (Cy5)
NBD PtdIns(4 5)P2 C16 is an analog of PItdIns(4 5)P2 (PIP2) labeled with NBD on the sn-1 acyl chain. Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in several tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3 4 5)P3.
Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane.1 In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. 2 Due to its four acyl chains and small head group CL can organize into domains which can be proton sinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus3.
Lipid A6 is an ionizable and biodegradable lipid that is used to formulate lipid nanoparticles (LNPs) for delivering RNA. Lipid A6 has similar structure as Dlin-MC3-DMA but with ester and alkyne bonds to improve its biodegradability and cell membrane fusion ability. Lipid A6 forms lipid-like nanoparticles together with cKK-E12 synergistically to facilitate robust mRNA delivery with improved tolerability. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.