Lipids & Polymers

BP Lipid 304 is an ionizable lipid analog of SM-102 featuring an ethanolamine head and two identical amide tails on the C6 position relative to the amine. This lipid is an analogue of ALC-0315. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 308 has a terminal tertiary amine group, a linoleic group, and a 4,4-bis(octyloxy)butanoic acid sodium salt tail. This compound can be useful for the building or modification of lipid nanoparticles. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Hydroxy-PEG4-CH2CO2H is a PEG linker containing a hydroxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research use only.

7-Tridecanol is a homologous fatty acid. It is biodegradable and has been shown to have structural isomers. Reagent grade, for research use only.

Propargyl-PEG4-Ms has an alkyne group and a mesylate group. The mesylate group is a sulfonate ester for nucleophilic substitution reactions (SN2). The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environments. Reagent grade, for research use only.

Azido-PEG3-flouride is a PEG linker containing a fluorine atom and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research use only.

DSPE-PEG-CY5.5, MW 2,000 is a water-soluble dye coupled to a PEG polymer with a hydrophilic phosphate head and hydrophobic lipid tails. Absorbance and emission of the dye are identical to Cy5.5 fluorophore. The polymer can self-assemble to form lipid bilayer in water. The phospholipid polyPEG can be used as a drug nanocarrier for administration of nutrients and therapeutic drugs, such as liposome in mRNA or DNA vaccines. Reagent grade, for research use only.

Hydroxy-PEG1-acid sodium salt is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research use only.

Propargyl-PEG12-methylamine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. The PEG spacer helps improve the water solubility of the molecule in aqueous media. Reagent grade, for research use only.