Lipids & Polymers

CL1 is a trialkyl ionizable lipid crucial for creating Lipid Nanoparticles (LNPs). It exhibits superior mRNA delivery to the liver compared to numerous other ionizable lipids. The pKa is 6.3.

93-O17S is a chalcogen-containing ionizable lipidoid used for making Lipid Nanoparticles (LNPs). These lipids can form nanoparticles that encapsulate and deliver siRNA, mRNA, DNA or small molecules into cells. Reagent grade, for research use only.

N-(amine-PEG23)-N-bis(PEG3-azide) is a PEG reagent containing a terminal amine and two azide groups. The hydrophilic PEG spacer increases solubility in aqueous media. The azide groups can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Reagent grade, for research use only.

(S, R, S)-AHPC-PEG6-Azide is a click chemistry PROTAC linker that incorporates an E3 ligase ligand with a PEG6 arm to empower PROTAC research & discovery. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Azide enables click chemistry with alkyne, DBCO, or BCN molecule. Reagent grade, for research use only.

(S, R, S)-AHPC-PEG2-Azide is a click chemistry PROTAC linker that incorporates an E3 ligase ligand with a PEG2 arm to empower PROTAC research & discovery. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media. Azide enables click chemistry with alkyne, DBCO, or BCN molecule. Reagent grade, for research use only.

N-(t-butyl ester-PEG6)-N-bis(PEG6-amine) is a PEG reagent that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions. The hydrophilic PEG spacers increase the compounds water solubility in aqueous media. Reagent grade, for research use only.

N-(acid-PEG6)-N-bis(PEG6-amine), HCl salt is a 3-arm PEG reagent that is reactive toward activated NHS esters. The carboxylic acid group is reactive with primary amine groups in the presence of HATU or EDC. Reagent grade, for research use only.

Mal-PEG4-NH-Boc is a PEG linker containing a maleimide group and a Boc protected amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond. Reagent grade, for research use only.

t-Boc-N-amido-Tri-(azide-PEG23-ethoxymethyl)-methane is a branched PEG linker with a terminal Boc-protected amino group and three terminal azides. The azide groups enables PEGylation via Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. Reagent grade, for research use only.