Lipids & Polymers

(S,R,S)-AHPC-PEG3-N3 is a VHL ligand with a PEG 3 azide linker and terminal acid for PROTAC compounds. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose.

t-Boc-N-amido-PEG4-CH2CO2-NHS is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The Boc group can be deprotected under mild acidic conditions to form the free amine. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose.

14-(Bromoacetamido-PEG5-ethylcarbamoyl)tridecanoic-t-butyl ester has a bromine on a PEG linker with an alkane tail that has a t-butyl ester group. The bromine (Br) can be used as a leaving group for nucleophilic substitution reactions. The t-butyl group can be deprotected under acidic conditions. It is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

PEG3-bis(Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane) is a crosslinker consisting of six propargyl groups. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose.

14-(Bromoacetamido-PEG4-ethylcarbamoyl)tridecanoic-t-butyl ester has a bromine on a PEG linker with an alkane tail that has a t-butyl ester group. The bromine (Br) can be used as a leaving group for nucleophilic substitution reactions. The t-butyl group can be deprotected under acidic conditions. It is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

BP Lipid 229 is an amino ionizable lipid with an ethanolamine lipid head, enhancing encapsulation of mRNA. The lipid has primary esters at C8 position relative to the amine nitrogen. The lipid can be used for mRNA-based therapies which depends on the availability of a safe and efficient delivery vehicle. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DMG-Nitrophenyl Carbonate is a short reagent featuring a DMG lipid headgroup and a nitrophenyl carbonate, which is readily displaced by amine nucleophiles to form carbamate bonds under mild conditions.

PEG13-bis(Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane) is large molecule with two sets of three terminal alkynes joined together by a large PEG linker. The alkynes are most frequently used in copper click chemistry with azides. The PEG linkers as well as numerous amide bonds provide high aqueous solubility to this compound, which may alter ADME of this compound.

BP Fluor 488 methyltetrazine is the BP Fluor 488 fluorophore and a methyltetrazine functional group, which is a click chemistry handle that rapidly ligates to trans-cyclooctene (TCO) groups on target molecules.