Lipids & Polymers

DSPE-PEG-TCO, MW 2,000 is a large PEG-lipid with a DSPE group and a trans-cyclooctyne moiety. DSPE is a phospholipid known for spontaneously forming micelles in aqueous media. DSPE-PEG conjugates are commonly used in the development of lipid nanoparticles in drug delivery. TCO is a click chemistry handle that is used with tetrazine-containing compounds for highly efficient labeling.

(S, R, S)-AHPC-PEG4-N-Boc is a PROTAC linker featuring an AHPC group, a hydrophilic PEG linker, and a Boc-protected amine. (S, R, S)-AHPC is a ligand that activates E3 ligase, while the Boc protecting group can be removed with strong acid to reveal a primary amine which can participate in a wide variety of reactions.

PEG3-bis(Amino-Tri-(Propargyl-PEG8-ethoxymethyl)-methane) is large molecule with two sets of three terminal alkynes joined together by a short PEG linker. The alkynes are most frequently used in copper click chemistry with azides to form stable triazoles with the target compound. The PEG linkers as well as numerous amide bonds provide high aqueous solubility to this compound, which may alter DMPK of this compound.

mPEG-DMG, MW 2,000 is a large PEG lipid containing a DMG group and a methoxy cap. The methoxy cap is inert while the DMG group is a popular component for developing lipid nanoparticles. Varying the size of a PEG linker greatly impacts its molecular dynamics, thereby affecting DMPK and ADME properties of a given API.

mPEG-DMG, MW 5,000 is a large PEG lipid containing a DMG group and a methoxy cap. The methoxy cap is inert while the DMG group is a popular ligand for developing PEG-lipids and lipid nanoparticles more broadly. Varying the size of a PEG linker greatly impacts its molecular dynamics, thereby affecting DMPK and ADME properties of a given API.

3-Amino-2-sulfopropanoic acid is a short molecule featuring a carboxylic acid, a sulfonate group, and a primary amine. The carboxylic acid and the primary amine are free to link this molecule to larger structures while the sulfonate group provides high water solubility to this aliphatic compound.

14-(Bromoacetamido-PEG6-ethylcarbamoyl)tridecanoic t-butyl ester is a bifunctional PEG linker containing a bromoacetamide, a PEG6 spacer, and a tridecanoic t-butyl ester. Bromoacetamide is a thiol-specific covalent ligand while the t-butyl ester can be hydrolyzed to allow for reactions with amines or alcohols to form amides or esters respectively.

2-(4-(2-aminoethyl)piperazin-1-yl)ethanamine is a piperazine with two N-ethanamine groups. This type of molecule may be used to build drug molecules or design novel ionizable aminolipid head groups for lipid nanoparticles.

DOTA-PEG10-azide is a chelating reagent featuring a DOTA group and an azide with PEG10 spacer. Azides are reactive with alkynes through click chemistry while DOTA chelates di- and trivalent cations for applications such as imaging diagnostics.