Lipids & Polymers

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker featuring an AHPC group, a hydrophilic PEG linker, and an amine. (S, R, S)-AHPC is a ligand that activates E3 ligase, while the primary amine which can participate in a wide variety of reactions.

Lipid 2 is an ionizable aminolipid featuring a dimethylamine headgroup, a thiocarbamate linking to a central amine with two ester branches, one unsaturated C9 and a saturated C17. This compound may be employed in the development of lipid nanoparticles for drug delivery.

Azido-PEG8-Val-Cit-PAB-OH is a cleavable linker intermediate which contains an azide, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The azide is free to perform click chemistry with terminal alkynes or strained cyclooctynes such as DBCO or BCN. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.

t-Boc-N-amido-PEG-Succinimidyl Carbonate, MW 2,000 is a PEG linker containing a Boc-protected primary amine and a succinimidyl carbonate. The carbonate is a good leaving group, being easily substituted by nucleophiles such as amines and alcohols. The Boc group can be deprotected by acidic conditions, which frees the amine to react with functional groups such as carboxylic acids, aldehydes and ketones.

t-Boc-N-amido-PEG-Succinimidyl Carbonate, MW 5,000 is a PEG reagent containing a Boc-protected amine and a succinimidyl carbonate. The carbonate is a strong leaving group, being easily substituted by nucleophiles such as amines and alcohols to form new carbamates or carbonates respectively. The Boc group can be deprotected by acidic conditions, which frees the amine to react with functional groups such as carboxylic acids, aldehydes and ketones.

PEG3-bis(Amino-Tri-(Acid-ethoxymethyl)-methane) is a PEG linker containing two sets of three carboxylic acids joined together by a short PEG spacer. The carboxylic acids are open for reactions with nucleophiles such as amines to form amides with a target compound. The PEG linker provides aqueous solubility.

DSPE-PEG-Fluor 594, MW 2,000 is a PEG-lipid conjugate featuring a DSPE phospholipid and a Fluor 594 dye. DSPE is a phospholipid that is well-known to spontaneously form micelles in aqueous media, while Fluor 594 is a red, water-soluble dye with absorption and emission maxima at 590 and 617 nm respectively.

TCO-Amino-Tri-(Acid-ethoxymethyl) is a multifunctional PEG linker containing three carboxylic acids and a trans-cyclooctene (TCO) moiety joined together at a quaternary carbon atom. The carboxylic acids are reactive towards nucleophiles such as amines, and alcohols while the TCO function is applied towards click chemistry with tetrazine-containing compounds.

PEG13-bis(Amino-Tri-(Acid-ethoxymethyl)-methane) is a hexafunctional PEG linker containing a pair of three carboxylic acids joined together by a PEG spacer. The carboxylic acids are free for coupling reactions with amines and alcohols. The long PEG spacer provides high aqueous solubility and alters DMPK.