Lipids & Polymers

N-(NHS ester-PEG6)-N-bis(PEG6-N-Boc) is a trifunctional PEG linker that combines an activated NHS ester and two Boc-protected amines ligated together at a tertiary amine. The NHS ester is highly reactive towards nucleophiles like amines while the Boc protected amine can be deprotected and used in coupling reactions with carboxylic acids or activated esters.

BP Lipid 310 is an ionizable aminolipid analog of CL1. The structure features an ethanolamine head and an ester linking to a polyunsaturated hydrophobic tail. This lipid may be used to encapsulate nucleic acids or small-molecule drugs to form lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DOPE-PEG-DBCO, MW 2,000 is a PEG-lipid containing a DOPE and a DBCO group. DOPE is a phospholipid that is commonly employed in the development of lipid nanoparticles. DBCO is a click chemistry handle which is used to react with azides and form stable triazoles with target molecules.

16-(Azide-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a hybrid PEG linker featuring an azide-PEG and an aliphatic t-butyl ester linked together at a central amide. Azides are click chemistry handle which are used to react with terminal alkynes or strained cyclooctynes while t-butyl esters can be hydrolyzed by strong acid to reveal a carboxylic acid.

DSPE-PEG-BDP FL, MW 2,000 is a PEG lipid with a DSPE group and a BDP FL fluorophore. DSPE is a phospholipid that is used in the development of lipid nanoparticles in the field of drug delivery. BDP FL is a fluorescent dye with excitation and emission maxima at 504 nm and 514 nm respectively.

N-(t-butyl ester-PEG24)-N-bis(PEG23-Azide) is a trifunctional molecule combining two azides and a t-butyl ester, all joined together by a tertiary amine at its center. The azide functions can be used in click chemistry with terminal alkynes or strained cyclooctynes like BCN or DBCO while the t-butyl ester can be deprotected and made into amides or esters by reacting with amines or alcohols respectively. The PEG spacer provides aqueous solubility and altered DMPK.

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V

BRD4 degrader AT1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells.

A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). It can be used effectively in cancer research.