Lipids & Polymers

dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.

Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC, consists of two ligands of von Hippel-Lindau.

Fmoc-3VVD-OH is an intermediate for the synthesis of MMAE. The Fmoc protecting group may be removed with base, typically piperidine, to reveal the methylated N-terminal of this peptide.

Mal-amido-PEG3-NHS is a PEG linker featuring both an NHS ester and a maleimide. The NHS group is easily displaced by amine nucleophiles to form amides with target molecules while maleimide is a thiol-specific covalent linker which is used to label reduced cysteines in proteins.

Mal-amido-PEG5-NHS is a PEG linker featuring both an NHS ester and a maleimide. The NHS group is reactive with amine-containing molecules while maleimide is a thiol-specific covalent linker which is used to label reduced cysteines in proteins.

BS3 Crosslinker (disodium) is an aliphatic linker featuring two sulfo-NHS groups, which are readily displaced by amine nucleophiles to form amides with target molecules. Sulfo-NHS groups are more water-soluble than their NHS counterparts.

Di-tert-butyl iminodiacetate

N-(t-butyl ester-PEG4)-N-bis(PEG4-Propargyl) is a trifunctional PEG linker that combines a t-butyl ester with two terminal alkynes. The alkynes can be applied in copper-click chemistry with azides to form stable triazole linkages with a target molecule, while the t-butyl ester can be deprotected and reacted with amines or alcohols to form amides or esters.

N-(Acid-PEG4)-N-bis(PEG4-Propargyl) is a trifunctional PEG linker that combines a t-butyl ester with two terminal alkynes. The alkynes can be applied in copper-click chemistry with azides to form stable triazole linkages with a target molecule, while the acid can be reacted with amines or alcohols to form stable amides or esters.