Lipids & Polymers

DOPE-PEG-FITC, MW 2,000 is a PEG lipid combining a DOPE group and an FITC fluorescent dye. DOPE is a popular phospholipid in the field of lipid nanoparticle-based drug delivery. FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively.

benzyl N-[2-(prop-2-enamido)ethyl]carbamate is a short aliphatic linker featuring a Cbz-protected amine and an acrylamide. Acrylamide is a Michael acceptor which is a good Michael acceptor which can be used in thiol-based bioconjugation or polymerization. Meanwhile, the Cbz protecting group can be removed using Pd-C hydrogenation to reveal a free amine that can participate in a wide variety of reactions such as couplings or reductive amination.

Mal-amido-PEG4-alkyne is a short PEG linker featuring a maleimide and a terminal alkyne. Maleimide is a covalent ligand used for linking thiols such as those in cysteines residues in proteins, while terminal alkynes can be used in copper (I) click chemistry with azides on target molecules.

16-(Amine-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG lipid

16-(Bromoacetamido-PEG6-ethylcarbamoyl)pentadecanoic-t-butyl ester is a PEG linker featuring a bromoacetamide and a terminal t-butyl ester. Bromoacetamide is a thiol-specific covalent ligand which can be used in labeling proteins via their cysteine residues, while the t-butyl ester can be hydrolyzed to reveal a carboxylic acid that can be used to couple with amines or alcohols.

DOPE-PEG-FITC, MW 5,000 is a PEG-lipid that features a DOPE phospholipid and an FITC fluorophore. DOPE is an unsaturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while FITC is a green fluorophore with excitation and emission maxima at 491 nm and 516 nm respectively. FITC-PEG conjugates see frequent use in fluorescence microscopy, immunohistochemistry and other in vivo research applications.

N-(Acid-PEG8)-N-bis(PEG8-Azide) is a trifunctional molecule that combines two azide functions with a carboxylic acid via a tertiary amine at its center. The azides can be reacted with terminal alkynes or cyclooctynes to form stable triazoles with a target molecule. Meanwhile, the carboxylic acid can be coupled with amines using reagents such as HATU or EDC.

endo-BCN-PEG8-amine is a PEG linker featuring a BCN and a primary amine. The BCN group is a click chemistry handle which quickly reacts with azides while the primary amine can be used to form amides with carboxylic acids in the presence of coupling reagents such as HATU or EDC.

DSPE-PEG-DBCO, MW 2,000 is a PEG lipid conjugate featuring a DSPE phospholipid and a DBCO group. DSPE is a saturated phospholipid that is commonly used to prepare lipid nanoparticles in drug delivery, while DBCO is a click chemistry handle that is frequently used to conjugate with azides on target molecules to form stable triazole linkages.