Lipids & Polymers

3-[4,4-Bis(octyloxy)-1-oxobutoxy]-2-(hydroxymethyl)propyl (9Z)-9-hexadecenoate is a lipid molecule featuring a primary alcohol, a palmitoleic acid, and a butanoic acid linked to two C8 chains via an acetal. Compounds such as this may also be used as intermediates in building lipids for use in lipid nanoparticles.

BP Lipid 313 is an ionizable lipid analogue of ALC-0315 featuring an ethanolamine head and two carbamate tails, one being an undecyl tail and the other being a branched C17. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug delivery. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Mal-amido-PEG4-amine TFA salt is a short PEG linker featuring a maleimide and a primary amine. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues on proteins, while primary amines can be used in a variety of ways such as reductive aminations or couplings.

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.

Bis-sulfone Amine is a reagent featuring two sulfone groups and a primary amine. The sulfone group is a covalent ligand which is used to bind thiols via a Michael addition, and this can be employed to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The amine group is free to perform a variety of reactions such as coupling with carboxylic acids, reductive amination with aldehydes or ketones, or SNAr with electron-deficient aromatic groups.

8-Azido-3,8-dideoxy-D-manno-octulosonic acid (Kdo Azide) is an analogue of the natural 3-deoxy-D-manno-octulosonic acid (Kdo) that contains a very small modification, specifically an azido moiety. This molecule can be incorporated by cultured cells (Gram-negative Bacteria, for example) and incorporated into glycans (LPS, for example) during active glycan biosynthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne.

DBCO-PEG5-TFP Ester is an amine-reactive, labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. The hydrophilic polyethylene glycol (PEG) spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary azide-containing molecules.

BP Fluor 594 Biotin is a chemical reagent containing the BP Fluor 594 dye and a biotin group. Biotin is an affinity ligand and it is used in biochemical applications such as pull-down assays or for ligating with streptavidin proteins. BP Fluor 594 is a red fluorescent dye with excitation and emission maxima at 590 nm and 617 nm respectively.

TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.