Lipids & Polymers

2-(7Z,10Z)-7,10-Hexadecadien-1-yloxirane is an intermediate for the preparation of lipid molecules. It features a polyunsaturated chain with an epoxy ring that can be opened by nucleophiles.

DOPE-PEG-Fluor 488, MW 2,000 is a PEG lipid featuring a DOPE phospholipid and a Fluor 488 dye. DOPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development, while Fluor 488 is a cyanine dye that is prominently used in fluorescence microscopy. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm.

Biotin-PEG3-Bromide is a short PEG linker featuring a biotin group and a bromide. The bromide is a halogen which is easily displaced by nucleophiles such as alcohols or amines. Alternatively, bromide can be applied in a number of cross-coupling reactions such as in a Suzuki reaction. Biotin is useful for affinity-based applications such as pull-down assays or for ligating with streptavidin proteins.

N-(Azide-PEG8)-N-bis(PEG8-Amine) is a trifunctional PEG reagent containing two primary amines and one azide. The primary amine is reactive with carboxylic acids, NHS esters, or carbonyls to form a variety of stable bonds. The azide can be used to do click chemistry with terminal alkynes or strained cyclooctynes like DBCO or BCN.

Azido-PEG8-diglycoamide-Lys(Boc)-PAB is a PEG labeling reagent featuring an azide, a Val-Lys dipeptide, and a PAB group. Azides are highly reactive in click chemistry with terminal alkynes and strained cyclooctynes while the Val-Lys dipeptide is enzyme cleavable and triggers payload release via an elimination mechanism within the PAB structure. Finally, the ε-amine of the lysine is Boc-protected.

DOPE-PEG-Fluor 488, MW 5,000 is a PEG lipid featuring a DOPE phospholipid and a Fluor 488 dye. DOPE is a phospholipid that is known to spontaneously form micelles in water and is featured heavily in lipid nanoparticles and drug development, while Fluor 488 is a cyanine dye that is prominently used in fluorescence microscopy. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm.

Benzyl-PEG-OH, MW 2,000 is a PEG reagent featuring a primary alcohol and a benzyl-protecting group. The alcohol is a versatile scaffold and can be manipulated in a variety of ways such as in creating esters or substituting with electrophiles such as halogens, mesylates, triflates, etc. The benzyl protecting group can be removed by hydrogenation to reveal a second alcohol group for further reactions.

N-(Boc-PEG4)-N-bis(PEG4-propargyl) is a trifunctional chemical containing two terminal alkynes and a Boc-protected primary amine. The terminal alkynes are used in copper click chemistry with azides to form stable triazole linkages with the target molecule while the carboxylic acids are reactive towards alcohols and primary amines to form esters and amides respectively.

Azido-PEG8-triethoxysilane is a short PEG linker featuring an azide, which is used in click chemistry with alkynes, and a triethoxysilane group, which may be used to retain a compound on silica surfaces such as those used in normal phase chromatography.