Lipids & Polymers

Bromoacetamido-PEG2-C2-acid (Legacy Tebubio ref. 282T14817). Bromoacetamido-PEG2-C2-acid is a polyethylene glycol (PEG)-based linker utilized in PROTAC synthesis[1].

Bromoacetamido-PEG2-C2-NHS ester (Legacy Tebubio ref. 282T14818). Bromoacetamido-PEG2-C2-NHS ester is a PEGylation-based linker compound employed in PROTAC synthesis [1].

Bromoacetamido-PEG4-NHS ester (Legacy Tebubio ref. 282T14825). Bromoacetamido-PEG4-NHS ester is a PEGylated N-hydroxysuccinimide ester linker designed for PROTAC synthesis, facilitating the creation of protein-targeted chimeras (PROTACs)[1].

Carboxy-PEG4-phosphonic acid (Legacy Tebubio ref. 282T14868). Carboxy-PEG4-phosphonic acid, a polyethylene glycol (PEG)-derived linker, is utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Carboxy-PEG4-sulfonic acid (Legacy Tebubio ref. 282T14869). Carboxy-PEG4-sulfonic acid is a PEG-based linker frequently used in PROTAC synthesis [1].

Cbz-NH-PEG2-C2-acid (Legacy Tebubio ref. 282T14887). Cbz-NH-PEG2-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two key ligands essential for PROTAC molecule formation, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Cbz-NH-PEG4-C2-acid (Legacy Tebubio ref. 282T14889). Cbz-NH-PEG4-C2-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation via the ubiquitin-proteasome system within cells.

Chloroacetamido-PEG4-C2-Boc (Legacy Tebubio ref. 282T14952). Chloroacetamido-PEG4-C2-Boc is a PEG-based PROTAC linker with alkyl and ether functionalities, used in synthesizing PROTACs as a versatile platform for targeted protein degradation (PROTACs).

DBCO-NHCO-PEG4-amine (Legacy Tebubio ref. 282T15062). DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].