Nucleotides

DusQ 2 dT phosphoramidite is a modified amidite employed in oligonucleotide synthesis. It features a completely non-fluorescent quencher nucleotide base, making it ideal for internal labeling of DNA oligonucleotide probes. The reagent includes DMT protection for the hydroxymethyl group, facilitating efficient oligonucleotide purification using cartridges.

DusQ 2 is a black quencher dye for the synthesis of dual-labeled oligonucleotide probes for qPCR bearing 5'-quencher. This quencher is ideal for HEX, JOE, ROX, Cyanine5, and other dyes with emissions in the orange and red parts of the spectrum.

Phosphoramidite for the synthesis of alkyne-modified oligonucleotides. Oligonucleotides can be used for click chemistry modification.

This reagent is designed for the synthesis of oligonucleotides bearing triple bond (alkyne) in the middle of the chain. Alkyne is attached to deoxyuridine fragment, and it does not interfere with the hybridization to the complementary strand.

Phosphoramidite for the synthesis of oligonucleotides with 5'-terminal alkyne for click chemistry. This alkyne amidite has several advantages over 5’-hexynyl phosphoramidite, 5'-butynyl-CEP, and other 5'-terminal alkyne phosphoramidites.

Bicyclononyne (BCN) is a stable and one of the most reactive cyclooctynes for copper-free click chemistry. Unlike dibenzocyclooctyne (DBCO), BCN is reactive both to azides (strain-promoted azyde-alkyne cycloaddition, SPAAC) and tetrazines (inverse electron demand Diels-Alder reaction, IEDDA)

Chemical phosphorylation reagent for the synthesis of 5'-phosphorylated oligonucleotides. The reagent contains a DMT group in its structure, which allows oligonucleotide purification on C18-cartridges or by reversed-phase chromatography.

Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C18 cartridges, and reverse phase HPLC.

A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.Abasic phosphoramidites are used in DNA and oligonucleotide synthesis.