Results for Cell Culture Products ( 2079 )
Cells adhere to one another and to the extracellular matrix durinig normal physiology and development, but also in pathological conditions such as chronic inflammation and tumor metastasis. For example, during extravasation from blood vessels into the tissue space, leukocytes first weakly adhere to and roll upon vascular endothelial cells via cell surface receptors known as selectins. Subsequent, stronger adhesion ensues using other receptors and ligands, such as LFA-1 and ICAM-1. Transendothelial migration follows, where the leukocytes squeeze between the tight endothelial cell junctions. As a final impediment to entering the tissue space, the leukocytes encounter the basement membrane, a mixture of extracellular components that ensheathes the vessel. The leukocytes utilize still other receptors to bind ECM, and also secrete matrix-degrading enzymes to facilitate their passage.
CAI media are tested for sterility in order to confirm no bacteria, yeast or fungi contaminate the solutions. The products undergo further quality control for correct pH, osmolality and lack of endotoxins. A panel of different bioassays affirm the media sustain a proper environment for expected cell-type-specific culture, growth, plating, karyotype, physiology, morphology, viability, population doublings, surface markers, cryopreservation, differentiation and/or induction. Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.