Chemicals & Small Molecules

Cholesterol oxidase (ChOx), a bacterial flavin oxidase containing FAD utilized in biochemical research, catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and subsequently isomerizes it to cholest-4-en-3-one [1].

α-Galactosidase (EC 3.2.1.22), a glycoside hydrolase enzyme, is prevalent across animals, plants, and microorganisms, and is often utilized in biochemical research. It facilitates the hydrolysis of α-1,6-linked terminal galactose residues in substrates such as galactooligosaccharides, galactomannans, and galactolipids. This includes catalyzing key catabolic processes involved in the cleavage of glycoproteins, glycolipids, and polysaccharides [1].

Laccase (Denilite IIS) is a polycopper oxidase (MCOs) widely found in microorganisms, plants, and fungi with antimicrobial activity and cytotoxicity that can be used in the study of cancer.Laccase promotes oxidative coupling of mono-lignin in lignin formation.

Nisin Z, an antimicrobial and anti-inflammatory peptide, demonstrates efficacy against Gram-positive bacteria and fungi, including C. albicans [1] [4].

FITC-β-Ala-Amyloid β-Protein (1-42) ammonium, a fluorescein isothiocyanate (FITC)-tagged monomer peptide of Aβ1-42, is instrumental in Alzheimer’s disease pathogenesis [1].

H-Ile-Lys-Val-Ala-Val-OH (IKVAV) is a short peptide with a sequence length of 5, present in the extracellular matrix (ECM), on the α-laminin chain. H-Ile-Lys-Val-Ala-Val-OH participates in a variety of life activities, such as promoting cell adhesion, neurite outgrowth, angiogenesis, collagenase IV production and tumor growth. H-Ile-Lys-Val-Ala-Val-OH can induce rapid differentiation of neural progenitor cells into neurons and neurite outgrowth.

Hippuryl-His-Leu-OH serves as a substrate to measure angiotensin I converting enzyme activity. Upon its cleavage, the resultant His-Leu moiety reacts with o-phthaldialdehyde or Fluorescamine, facilitating fluorescence detection [1] [2] [3].

Tislelizumab (BGB-A317) is an IgG4 class monoclonal antibody targeting human programmed death receptor-1 (PD-1) with antitumor activity that inhibits the binding of Fcγ receptor to macrophages and can be used to study advanced squamous non-small cell lung cancer.

Sugemalimab, a fully human, full-length, IgG4 monoclonal antibody (mAb) targeting programmed death ligand 1 (PD-L1), exhibits anticancer activities and is applicable in non-small cell lung cancer research [1].