Chemicals & Small Molecules

Envafolimab (ASC 22; KN 035), a recombinant humanized single-domain anti-PD-L1 antibody, integrates the anti-PD-L1 domain with the Fc fragment of the human IgG1 antibody. It inhibits the PD-L1 and PD-1 interaction with an IC50 of 5.25 nM, indicating its research potential for solid tumors [1] [2] [3].

Cadonilimab (AK104) is a humanized antibody engineered from the IgG1 scaffold and targets PD1/CTLA4. It is utilized in the research of metastatic cervical cancer [1] [2].

Muromonab, a monoclonal antibody that targets the CD3 receptor, blocks cytotoxic T cell function and serves as an immunosuppressant agent. It is administered to mitigate acute rejection of solid organ transplants [1].

Anti-Human IL-17A is a fully human anti- interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis [1] .

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody), a humanized monoclonal antibody, selectively neutralizes IL-17A and IL-17F, which promote osteogenic differentiation in human periosteum-derived cells (hPDC), and consequently inhibits inflammation-driven osteogenic differentiation [1].

Pamrevlumab (FG-3019) is a human antibody with affinity for connective tissue growth factor (CTGF) and is involved in anti-CTGF therapy for the treatment of idiopathic pulmonary fibrosis (IPF).

Solanezumab, a humanized monoclonal IgG1 antibody targeting the mid-domain of the amyloid-β (Aβ) peptide, shows promise for Alzheimer’s disease research [1].

Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a human IgGκ monoclonal antibody that specifically targets and inhibits IL-17A's receptor interaction, making it useful for researching autoimmune conditions such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis, and inflammatory arthritis [1].

Teclistamab, a human bispecific antibody targeting both BCMA on target cells and CD3 on T cells, facilitates T cell-mediated cytotoxicity, which results in T cell activation and subsequent target cell lysis. This compound has applications in research studies concerning multiple myeloma (MM) [1].