Chemicals & Small Molecules

Galegenimab (FHTR 2163; RG 6147; RO 7171009), an antibody fragment targeting High-temperature requirement A1 (HTRA1), is utilized in research on age-related macular degeneration (AMD) [1].

Gumokimab (AK 111), a monoclonal antibody, targets IL-17A and is utilized in researching psoriasis and ankylosing spondylitis. It competitively inhibits the interaction between human IL-17A and its receptor, IL-17R.

Interferon alfa, a type I interferon, activates new genes, displaying strong antiviral and antiproliferative effects on target cells. It signals through receptor-mediated activation of Stat1 and Stat2, which heterodimerize into a STAT complex binding with the DNA-binding protein IRF-9 (p48) to form ISGF-3 (IFN-stimulated gene factor 3). This complex further activates driver genes to fulfill its antiviral role [1].

Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that targets tumors by activating antigen-presenting cells like dendritic cells (DC), initiating tumor-reactive T cells, promoting tumor-specific T cell infiltration and destruction of tumors, and remodeling the tumor-infiltrating myeloid microenvironment [1] [2].

Amivantamab (JNJ-61186372) is a humanized antibody that recognizes epidermal growth factor receptor (EGFR) and MET proto-oncogene (MET), with anticancer and anti-tumor activities, preventing ligand binding to EGFR and MET and receptor dimerization that inhibits downstream signal transduction. Amivantamab can induce Fc-dependent endocytosis of macrophages and antibody-dependent cytotoxicity of natural killer cells, and can be used to study metastatic non-small cell lung cancer.

Cudarolimab (IBI101) is a fully human monoclonal antibody targeting OX40 (CD134), a costimulatory molecule expressed by activated immune cells. By inhibiting the interaction between OX40 and its ligand OX40L, Cudarolimab demonstrates antitumor activity, making it relevant for cancer research [1].

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody that targets a pyroglutamate amyloid beta (Aβ) epitope at the N-terminus, showing potential for early Alzheimer's disease research [1] [2].

Revdofilimab (ABBV-368) is a human IgG1 monoclonal antibody that acts as an agonist against OX40, a TNF receptor superfamily member expressed on activated and memory T cell subsets as well as T regulatory cells [1].

Heptacosanoic acid is a compound derived from Rhodosporidium kratochvilovae HIMPA1, a novel oil-bearing yeast isolated from Himalayan permafrost.