Chemicals & Small Molecules

Caspase-3 activator 1 (compound 4b), a Ru(III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage, enabling Caspase-3 to process gasdermin E (GSDME), resulting in GSDME-N terminus production and perforation of the gastric tumor cell membrane. Furthermore, compound 4b induces pyroptosis and subsequent immune responses and can be incorporated with decitabine (DCT) into the 4b-DCT-Lip lipid delivery system [1].

Hydroxy-PP-Me is a potent and specific CBR1 inhibitor with an IC50 of 759 nM. It inhibits serum-withdrawal-induced apoptosis and, when used in conjunction with As2O3, enhances As2O3-induced apoptotic cell death [1] [2].

Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury. It mitigates oxidative stress, prevents apoptosis, and promotes autophagy [1].

Beta-glucuronidase, a critical lysosomal enzyme, is implicated in the breakdown of glucuronate-containing glycosaminoglycans [1].

mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable activator of ERK 1/2 with an EC50 of 2.5-5 μM. It disrupts the interaction between the α and βγ subunits, facilitating α subunit dissociation without inducing nucleotide exchange [1].

Atrosab is a humanized IgG1 antibody targeting TNFR1, inhibiting TNF-mediated apoptosis, and can be used to study inflammatory and neurodegenerative diseases.

Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.

Brolucizumab (DLX1008) is a single-chain anti-VEGF-A antibody fragment with low picomolar affinity (K D = 1.05 pM), used for cancer research [1][2].

Ziralimumab (ABX-RB2), an anti-human CD147/BSG monoclonal antibody, is employed for immunosuppression [1].