Chemicals & Small Molecules

Trabikibart (CSL311), a βc-specific, fully human monoclonal antibody, specifically binds to the cytokine-binding epitope of the human βc receptor with picomolar affinity. It potently inhibits the collective impact of IL-3, GM-CSF, and IL-5 on eosinophil survival, underscoring its potential in chronic inflammatory diseases research [1].

Tobevibart, an IgG1-lambda humanized monoclonal antibody targeting the hepatitis B virus (HBV) surface envelope protein, exhibits antiviral activity [1].

TAT-NSF700 Fusion Peptide acetate is a membrane-permeable inhibitor of N-ethyl-maleimide-sensitive factor (NSF), a fusion peptide with potential anti-inflammatory activity.TAT-NSF700 Fusion Peptide acetate interacts with intracellular organelles and can be used to investigate Myocardial ischemia and reperfusion injury.

TAT-DEF-Elk-1 acetate is a cell-penetrating peptide inhibitor of ERK1/2 kinase phosphorylated Elk-1 with antitumor and antidepressant activity.TAT-DEF-Elk-1 acetate inhibits the phosphorylation of Elk-1, inhibits Elk-1 nuclear TAT-DEF-Elk-1 acetate inhibits Elk-1 phosphorylation and Elk-1 nuclear translocation, and can be used to study depression.

Tamgiblimab (IBI939) is a fully human monoclonal antibody that targets the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), exhibiting anticancer properties [1].

Strictinin, a phenolic compound extracted from Pu'er teas, exhibits antiviral, antibacterial, and laxative properties. Its mode of action involves speeding up intestinal transit without promoting gastric emptying, boosting food consumption, or triggering diarrhea in rats.

Scutellarin-7-diglucosidic acid, a natural flavone, is isolated from the purple leaves of Perilla ocimoides var. crispa [1].

RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.

Rezatapopt (PC14586) is a small molecule p53 reactivator with anti-tumor activity that selectively binds to the cleft present in the TP53 Y220C mutant protein and restores the p53 wild-type (normal) conformation and transcriptional activity, and can be used to study locally advanced or metastatic solid tumors.