Chemicals & Small Molecules

Sulfachloropyridazine-d4 is a deuterated compound of Sulfachloropyridazine. Sulfachloropyridazine has a CAS number of 80-32-0. Sulfachloropyridazine is a sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.

Sulfamethizole-d4 is a deuterated compound of Sulfamethizole. Sulfamethizole has a CAS number of 144-82-1. Sulfamethizole is a sulfathiazole antibacterial reagent.

Sulfaquinoxaline-d4 is a deuterated compound of Sulfaquinoxaline.

Sulthiame-d4 is a deuterated compound of Sulthiame.

Sunitinib-d4 is a deuterated compound of Sunitinib.

S-Verapamil-d7 HCL is a deuterated compound of S-Verapamil HCL. S-Verapamil HCL has a CAS number of 1188265-55-5.

Tacrolimus-13C-d2 is the 13C and deuterated compound of Tacrolimus.

Tafamidis-d3 is a deuterated compound of Tafamidis. Tafamidis has a CAS number of 594839-88-0. Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s: 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.

Taltirelin-13C-d3 is the 13C and deuterated compound of Taltirelin. Taltirelin has a CAS number of 103300-74-9. Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].