Chemicals & Small Molecules

Potent and selective PI3Kß inhibitor

Cav2.2 blocker

Kir2 potassium channel blocker

Mitochondrial cytochrome bc1 complex inhibitor

Protein-RNA binding click probe

L(+)-Ascorbic Acid, commonly known as Vitamin C, is a vital nutrient that plays a crucial role in various biological processes. It is an essential vitamin that cannot be synthesized by the human body and must be obtained through diet or supplementation. L(+)-Ascorbic Acid acts as a powerful antioxidant, protecting cells from damage caused by harmful free radicals.

This product is for research use only. Do not administer it to human. This is a Wnt signaling inhibitor. IWR-1 stabilizes a complex (consisting of Axin2, Apc, Ck1 and Gsk3β) that degrades beta catenin and promotes decomposition of beta catenin.

CEPT is a cocktail of small molecules developed at the National Institutes of Health (NIH). In human ES cells and human iPS cells (human pluripotent stem cells [hPSCs]), CEPT prevents cellular stress and DNA damage during cell passage. Like Y-27632, a known potent ROCK inhibitor, it improves the viability of hPSCs during cell passage and cryopreservation. Compared to existing methods, CEPT also improves cell viability in stem cell research, including embryoid body and organoid formation, single cell cloning, and genome editing using hPSCs.

Y-27632 is selective and potent ROCK inhibitor. Y-27632 plays various roles including contraction of vascular smooth muscle cells via ROCK signaling pathways. Furthermore, it suppresses the cell death of human embryonic stem cells (hESCs) and human induced Pluripotent Stem Cells (hiPSCs) at cell dispersion, and that it increases the survival rate of hESCs and hiPSCs during cryopreservation.