Chemicals & Small Molecules

ZINC40099027 is a specific adhesion plaque kinase (FAK) activator that promotes gastric mucosal repair in persistent aspirin-associated gastric injury through activation of adhesion plaque kinase, activates human adhesion plaque kinase by accelerating the enzyme activity of the structural domain of FAK kinase, activates cytosolic FAK, and promotes intestinal epithelial wound closure.

Patritumab deruxtecan (HER3-DXd), an antibody-drug conjugate (ADC), comprises a fully human anti-HER3 IgG1 monoclonal antibody, Patritumab, linked to a topoisomerase I inhibitor payload through a tetrapeptide-based cleavable linker, demonstrating anticancer activity [1].

PhosTAC7 successfully induced ternary protein complex formation and dephosphorylation of phosphatidylserine 318 (pS318) by Halo-FOXO3a in a dose-dependent manner.

Anti-Mouse CD28 Antibody (37.51) is a murine IgG-like antibody targeting CD28.

Anti-Mouse CD3 Antibody (17A2) is a murine IgG2b class antibody targeting CD3, which can be used to study TCR signaling, T cell activation and antigen recognition.

Anti-Mouse LAG-3 is a rat-derived IgG1 antibody inhibitor targeting mouse LAG-3.

Tenatumomab (ST2146) is a murine anti-tenascin-C monoclonal antibody used in the study of immune system diseases and lymphomas.

Peresolimab, a humanized IgG1-κ antibody, targets PD-1 and may activate physiological immune inhibitory pathways, thereby restoring immune homeostasis [1] [2].

Glyceraldehyde phosphate dehydrogenase, targeted by anti-thymocyte and anti-apoptotic agents, catalyzes the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by perhydroxyl radicals [1] [2].