Chemicals & Small Molecules

Enoticumab (REGN421, SAR153192) is an IgG1κ antibody that targets human Delta-like ligand 4 (Dll4), a crucial component of the Notch signaling pathway, modulating macropinocytosis-dependent long-chain fatty acid absorption. It demonstrated an 86% and 83% inhibition of tumor growth in subcutaneous TOV-112D and intraperitoneal A2780 human ovarian tumor xenograft mouse models, respectively, at a dose of 2.5 mg/kg weekly [1].

Rosnilimab, a humanized IgG1-κ antibody, specifically targets PD-1 [1] [2].

WAY-606376 is an active molecule [often used in pharmaceuticals] with potential therapeutic applications.

Sulfo-Cy5-TCO, a water-soluble click chemistry reagent with a TCO group, exhibits high reactivity towards tetrazines and methyltetrazines, facilitating rapid bioconjugation [1].

RGB-1, a small molecule that selectively stabilizes the RNA G-quadruplex structure, enhances G-quadruplex-mediated inhibition of RNA translation in mammalian cells and reduces NRAS proto-oncogene expression in breast cancer cells.

Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42. It specifically binds to the pyroglutamate-modified form of Aβ, which is implicated in the aggregation of amyloid plaques [1].

PHI-101 is an orally available and selective checkpoint kinase 2 (Chk2) inhibitor for the study of refractory acute myelogenous leukemia (AML) and ovarian cancer.

Nurr1 agonist 8 is a low-affinity Nurr1 agonist that can be used to study neurological diseases such as Parkinson's.

Naratuximab emtansine [1] is a humanized monoclonal antibody (Anti-TSPAN26/CD37 Reference Antibody (naratuximab)) that specifically targets CD37 (TSPAN26) and serves as the basis for creating an antibody-drug conjugate (ADC) compound.