MFN2 agonist-1 (B-A/l) effectively induces mitochondrial fusion and counteracts mitochondrial clumping [formation of static mitochondrial aggregates], reinstating mitochondrial movement in cultured mouse neurons deficient in mitofusin 2 (MFN2) and harboring the CMT2A-associated MFN2 T105M mutation.
AJ2-71 is a SLC15A4 inhibitor that suppresses IFN-α production and obstructs SLC15A4-mediated MDP transport, making it suitable for research of inflammation [1].
4,7-Didehydroneophysalin B, a flavonoid exhibiting cholinesterase inhibitory properties, is derived from the Physalis alkekengi L. var. franchetii (Mast.) Makino plant, from which it can be isolated and purified.
RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.