Chemicals & Small Molecules

TERT-IN-1 has anti-HIV activity and can be used to study HIV infection.

D-F07 is a novel fluorescent IRE-1 RNase inhibitor and a tricyclic chromone with potential anticancer activity.

P-XSC has anticancer activity, inhibits proliferation of colonic epithelial cells in patients with adenomatous polyps, and may be used in the study of breast cancer.

ARV-393 HCl is an orally active and potent PROTAC targeting BCL6 with antitumor activity for the study of non-Hodgkin's lymphoma.

CXCL-CXCR1/2-IN-1 is an orally active and potent inhibitor of the ELR+CXCL-CXCR1/2 pathway with anticancer and anti-angiogenic activity and can be used to study cardiovascular disease and cancer.

Admire is an important compound in the study of pesticides in agriculture.

CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.

5-HETE ((±)-5-HETE), an oxidative derivative of Arachidonic acid and a fatty acid, comprises a mixture of 5(S)-HETE and 5(R)-HETE. This compound acts as a powerful aggregating agent, effectively inducing neutrophil aggregation with an IC 50 value of 200 nM [1].

11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of maintaining continuous replication of functional mitochondria in Saccharomyces cerevisiae (KD115).