Results for Chemicals & Small Molecules ( 98424 )
6β-Hydroxy Testosterone, primarily metabolized from testosterone by CYP3A4 and CYP3A5 enzymes, represents 75-80% of testosterone's metabolites. Both cytochrome P450 enzymes, induced by glucocorticoids and various xenobiotics (including drugs and chemical carcinogens), facilitate the metabolism of xenobiotics and certain endobiotics like steroid hormones. However, the biological effects of 6β-hydroxy testosterone remain poorly understood.
BIBO3304 (diTFA), a selective neuropeptide Y (NPY) Y1 receptor antagonist, demonstrates oral efficacy. It exhibits high affinity for Y1 receptors in both humans and rats, with IC50 values of 0.38 nM and 0.72 nM, respectively. Additionally, BIBO3304 (diTFA) enhances bone-tendon healing via the Wnt/β-catenin signaling pathway [1] [2] [3].