Chemicals & Small Molecules

(Z)-SU14813 is a novel tyrosine kinase inhibitor with anticardiogenic and antitumor activity that inhibits VEGFR-2, PDGFR-β, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent manner.

2-(1-methyl-1H-imidazol-4-yl)acetic acid (2-(1-methylimidazol-4-yl)acetic acid) is a plasma histamine derivative that is a biomarker for identifying lymphangioleiomyomatosis.

BI-4732 is a potent, highly BBB-permeable EGFR inhibitor that is active against multiple EGFR mutations (E19del, L858R, and T790M), including C797S.

L-Alanyl-L-leucine (H-Ala-Leu-OH) is a dipeptide compound that is involved in protein synthesis.

Anti-MAGEA3 Antibody is a humanized anti-MAGEA3 antibody expressed by CHO cells. Anti-MAGEA3 Antibody is used for immunocytochemistry, immunohistochemistry (paraffin) and immunoblotting.

Cholesterol-d6 is a deuterated chlosterol that can be used to study lipid membrane flow and chlosterol metabolism in vivo.

Decoquinate-d5 is a deuterated compound of Decoquinate. Decoquinate has a CAS number of 18507-89-6. Decoquinate is a coccidiostat for poultry.

Aniline-d5 is a deuterated compound of Aniline. Aniline has a CAS number of 62-53-3. Aniline has been reported to be toxic to the spleen via iron overload and induction of oxidative stress via Heme Oxygenase 1 up-regulation. Toxicity of this agent on the spleen is characterized by hyperplasia, fibrosis, and vascular congestion in rats. Studies suggest that this compound causes significant increase in both p-IKKα and p-IKKβ which in-turn increases NF-κB and AP-1 binding activity. In other experiments, Aniline displays a capacity to induce methemoglobinemia, glutathione depletion, membrane cytoskeletal changes, loss of circulating blood cells, and adversely affects blood stability.

FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.